5-MTHF 1MG
5-MTHF 1MG
Nedley Health

5-MTHF 1MG

Folate is a B vitamin essential to methylation, DNA synthesis, cellular repair, brain function, and healthy fetal development. Yet natural folates in food are highly unstable—rapidly degraded by processing, manufacturing, and storage—and common folic acid supplements require enzymatic conversion before the body can use them. Enzyme defects, poor liver function, digestive challenges, and lifestyle factors like smoking and alcohol use can all impair this conversion, leaving much of the population functionally deficient despite adequate intake.

5-MTHF delivers folate as L-methyltetrahydrofolate calcium—the most stable, bioavailable, and biologically active form available. By bypassing the need for enzymatic activation entirely, this next-generation formula ensures the body can absorb and utilize folate immediately, regardless of genetic variations or digestive limitations that compromise conventional folic acid supplements.

This readily available form of folate supports critical methylation reactions, healthy homocysteine metabolism, neurological function, and cellular health—making it an essential foundation for women in their childbearing years and anyone seeking optimal folate status.

FDA Disclaimer:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Pregnancy and Fetal Development
Supports healthy brain and spinal cord development when taken before and during early pregnancy, delivering bioactive folate during the critical first 3–4 weeks when these structures are forming.

Methylation and Cellular Health
Fuels the body's methylation processes—the attachment of methyl groups essential for producing enzymes, hormones, neurotransmitters, antibodies, vitamins, and cell membranes, as well as DNA repair and energy production.

Cardiovascular and Homocysteine Support
Donates methyl groups to convert homocysteine into methionine for the production of SAMe—the body's principal methylating agent—helping maintain healthy homocysteine levels and cardiovascular function.

Neurological Function and Mood Balance
Supports brain activity, neurotransmitter production, and a healthy inflammatory response to promote cognitive performance and emotional well-being.

Superior Bioavailability
Bypasses the enzymatic conversion step that limits conventional folic acid, ensuring immediate availability for individuals with enzyme defects, malabsorption, or other barriers to folate metabolism.

Serving Size 1 Vegetarian Capsule
Amount Per Serving:
Folate (as L-Methyltetrahydrofolate Calcium) 1,000 mcg DFE
Other ingredients: microcrystalline cellulose, hypromellose (capsule),
vegetarian leucine

Take 1 capsule daily, or as directed by your healthcare practitioner.

Meet our founder

Neil Nedley, MD, the founder and medical director of the Nedley Depression and Anxiety Recovery Programs™, is a leading voice in the world of mental well-being.

With years of experience as a practicing physician, prolific author, public speaker, and teacher, Dr. Nedley has devoted his career to transforming lives through lifestyle and holistic medicine.

His keen insights into depression, anxiety, mood, and cognitive function led him to eventually create his own supplement line with Nedley Health.